B-cell acute lymphoblastic leukemia ALL with hypereosinophilia Anomalies of t(5,14) (q31:q32)

B-cell acute lymphoblastic leukemia ALL with hypereosinophilia Anomalies of t(5,14) (q31:q32)

Anomalies t514ID1111:

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t(5;14)(q31;q32)

Clinics and Pathology

Disease

B-cell acute lymphoblastic leukemia (ALL) with hypereosinophilia

Phenotype / cell stem origin

CD19+, CD10+ ALL; eosinophils are not part of the leukemic cells and do not carry the t(5;14); they represent a reactive population (eosinophilia in association with ALL is usually reactive)

Epidemiology

rarely described; 6M/1F; affects both children and adults, general features of ALL with hypereosinophilia are rarity, male predominance; and young age

Cytology

marked eosinophilia; basophilia; IL3 is over-expressed

Prognosis

prognosis appears to be poor, a feature of ALLs with hypereosinophilia

Cytogenetics

Additional anomalies

sole anomaly or accompanied with various secondary anomalies: +X, (i(7q), del(12p), +19

Genes involved and Proteins

Gene Name

IL3

Location

5q31

Protein

152 amino acids; growth factor; colony stimulating factor involved in the survival, proliferation and differentiation of multipotent hematopoietic cells

Gene Name

IgH

Location

14q32

Result of the chromosomal anomaly

Hybrid gene

Description

break in the promoter region of IL3 and in the Jh region of IgH

Fusion Protein

Oncogenesis

over-expression of IL3

External links

Other database

t(5;14)(q31;q32)

Mitelman database (CGAP – NCBI)

Other database

t(5;14)(q31;q32)

CancerChromosomes (NCBI)

To be noted

no recent article has been found; additional cases are needed to delineate this entity; we propose that a Study Group is established and that cases are collected; if you have a case, please, contact us

Bibliography

Hypereosinophilic syndrome in acute lymphoblastic leukemia with a chromosome translocation [t(5q;14q)].

Tono-oka T, Sato Y, Matsumoto T, Ueno N, Ohkawa M, Shikano T, Takeda T.

Med Pediatr Oncol 1984; 12: 33-37.

Medline 84141597

Acute lymphoblastic leukemia with chromosomal 5;14 translocation and hypereosinophilia: case report and literature review.

Hogan TF, Koss W, Murgo AJ, Amato RS, Fontana JA, VanScoy FL.

J Clin Oncol 1987; 5: 382-390.

Medline 87140204

Three-way reciprocal chromosomal translocation in an acute lymphoblastic leukemia patient with hypereosinophilia syndrome.

McConnell TS, Foucar K, Hardy WR, Saiki J.

J Clin Oncol 1987; 5: 2042-2044.

Medline 88061522

Calla-positive acute leukaemia with t(5q;14q) translocation and hypereosinophilia–a unique entity?

Baumgarten E, Wegner RD, Fengler R, Ludwig WD, Schulte-Overberg U, Domeyer C, Schuurmann J, Henze G.

Acta Haematol 1989; 82: 85-90.

Medline 90022265

The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene.

Grimaldi JC, Meeker TC.

Blood 1989; 73: 2081-2085.

Medline 89274388

Acute lymphoblastic leukemia with eosinophilia.

Fishel RS, Farnen JP, Hanson CA, Silver SM, Emerson SG.

Medicine 1990; 69: 232-243.

Medline 90325994

Activation of the interleukin-3 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia.

Meeker TC, Hardy D, Willman C, Hogan T, Abrams J.

Blood 1990 Jul; 76: 285-289.

Medline 90315422

Non-random involvement of chromosome 5 in ALL.

Chen Z, Morgan R, Sandberg AA.

Cancer Genet Cytogenet 1992; 61: 106-107.

Cytogenetic analysis in relapsed childhood acute lymphoblastic leukemia.

Heerema NA, Palmer CG, Weetman R, Bertolone S.

Leukemia 1992; 6: 185-192.

Power of the MAC (morphology-antibody-chromosomes) method in distinguishing reactive and clonal cells: report of a patient with acute lymphatic leukemia, eosinophilia, and t(5;14).

Knuutila S, Alitalo R, Ruutu T.

Genes Chromosomes Cancer 1993; 8: 219-223.

Contributor(s)

Written

12-1999

Jean-Loup Huret

Citation

This paper should be referenced as such :

Huret JL . t(5;14)(q31;q32). Atlas Genet Cytogenet Oncol Haematol. December 1999 .

URL :Anomalies t514ID1111

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