REM, NREM, Slow Wave, N3 Sleep in 17th and 18th edition of Harrison

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Sleep and the 18th edition of Harrison

17th edition of Harrison-CHAPTER Sleep Disorders: Introduction

• * Normal nocturnal sleep in adults displays a consistent organization from night to night . After sleep onset, sleep usually progresses through NREM stages 1–4 within 45–60 min.
• * Slow-wave sleep (NREM stages 3 and 4) predominates in the first third of the night and comprises 15–25% of total nocturnal sleep time in young adults.
• * The percentage of slow-wave sleep is influenced by several factors, most notably age. Prior sleep deprivation increases the rapidity of sleep onset and both the intensity and amount of slow-wave sleep.

18th edition of Harrison-CHAPTER Sleep Disorders: Introduction

• * Normal nocturnal sleep in adults displays a consistent organization from night to night). After sleep onset, sleep usually progresses through NREM stages N1–N3 sleep within 45–60 min.
• * Slow-wave sleep (NREM stage N3 sleep) predominates in the first third of the night and comprises 15–25% of total nocturnal sleep time in young adults.
• * The percentage of slow-wave sleep is influenced by several factors, most notably age . Prior sleep deprivation increases the rapidity of sleep onset and both the intensity and amount of slow-wave sleep.

Endogenous sleep- and wake-promoting substances 

• -corticotropin-releasing hormone (CRH)
• -prostaglandin D2
• -delta sleep–inducing peptide
• – muramyl dipeptide, interleukin 1
• -fatty acid primary amides
• – melatonin

What is in store for tomorrow

A question in GIT From MAY-AIIMS-2011 present in 18th edition absent in 17th edition-may be the 1st of its kind from many more to follow!!!-to know more kindly log on
Warm regards,
Dr.R.Manorajan-POSITIVE

Please Note :
You are now reading one post among a series of posts which give you must know points from Harrison which are often asked in AIIMS, PGI and AIPG Exams.

Copyright Positive :
These are based on the teaching material of OHC 2 : Operation Harri 2, a Crash Course for AIIMS, PGI and AIPG, being conducted by Positive